Veniaminof is one of the highest, largest and most active volcanoes on the Alaska Peninsula.

The massive cone of the stratovolcano is truncated by a steep-walled, 8 x 11 km, glacier-filled caldera that formed around 3700 years ago. The caldera rim is up to 520 m high on the north, is deeply notched on the west by Cone Glacier, and is covered by an ice sheet on the south. Post-caldera vents are located along a NW-SE zone bisecting the caldera that extends 55 km from near the Bering Sea coast, across the caldera, and down the Pacific flank.

Historical eruptions probably all originated from the westernmost and most prominent of two intra-caldera cones, which reaches an elevation of 2156 m and rises about 300 m above the surrounding icefield. The other cone is larger, and has a summit crater or caldera that may reach 2.5 km in diameter, but is more subdued and barely rises above the glacier surface.